State of New York

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Buffalo is a city in the state of New York. Located in Western New York on the eastern shores of Lake Erie and at the head of the Niagara River, Buffalo is the principal city of the Buffalo-Niagara Falls metropolitan area and the seat of Erie County.

Situated at the confluence of Lake Erie and the Buffalo and Niagara Rivers, Buffalo is a waterfront city. The city's rise to economic power came through its waterways in the form of transshipment, manufacturing, and an endless source of energy. Buffalo's waterfront is still a hub of commerce, trade, and industry that is essential to its economic prosperity.

Buffalo has increasingly become a center for bioinformatics and human genome research, including work by researchers at the University at Buffalo and the Roswell Park Cancer Institute. This consortium is known as the Buffalo Niagara Medical Campus.